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Malaysian Journal of Chemistry, 2017, Vol. 20(1), 1 – 23

 Molecular Mechanics and Quantum Chemical Study on Sites of Action of Sanguinarine Using Vibrational Spectroscopy Based on Molecular Mechanics and Quantum Chemical Calculations

Ricardo Gobato1 and Alireza Heidari2*
1Laboratory of Biophysics and Molecular Modeling Genesis, State Secretariat for Education of Parana, Bela Vista
do Paraiso, Parana, 86130-000, Brazil
2Faculty of Chemistry, California South University, 14731 Comet St. Irvine,
CA 92604, USA
*Corresponding author: (e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.; This email address is being protected from spambots. You need JavaScript enabled to view it.)

 Received: March 2018; Accepted: April 2018

ABSTRACT

Sanguinarine is an alkaloid studied in the treatment of cancer cell proliferation. Found in several plants with Argemone mexicana Linn, the plant is used in traditional medicine from several countries with Mexico and India in the natural treatment of wounds, conjunctivitis and as hallucinogen. Due to these studies of this alkaloid, a study was made on a molecular structure of the sanguinarine, through quantum chemistry, via computational methods such as molecular mechanics, PM3, Hartree-Fock, density functional theory and Møller-Plesset. The main site of molecular interaction was determined to be the hydrogen atoms. This has a strong antioxidant potential in its structure. It probably interacts with free radicals reducing their carcinogenic effect on cells. A study of the infrared spectrum complemented the paper.

Key wordsDensity functional theory; Hartree-Fock, Møller-Plesset; molecular geometry; quantum chemistry, PM3; sanguinarine

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133. Alireza Heidari, “A Chemotherapeutic and Biospectroscopic Investigation of the Interaction of Double–Standard DNA/RNA–Binding Molecules with Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh2O3) Nanoparticles as Anti–Cancer Drugs for Cancer Cells’ Treatment”, Chemo Open Access 5: e129, 2016.

134. Alireza Heidari, “Pharmacokinetics and Experimental Therapeutic Study of DNA and Other Biomolecules Using Lasers: Advantages and Applications”, J Pharmacokinet Exp Ther 1: e005, 2016.

135. Alireza Heidari, “Determination of Ratio and Stability Constant of DNA/RNA in Human Cancer Cells and Cadmium Oxide (CdO) Nanoparticles Complexes Using Analytical Electrochemical and Spectroscopic Techniques”, Insights Anal Electrochem 2: 1, 2016.

136. Alireza Heidari, “Discriminate between Antibacterial and Non–Antibacterial Drugs Artificial Neutral Networks of a Multilayer Perceptron (MLP) Type Using a Set of Topological Descriptors”, J Heavy Met Toxicity Dis. 1: 2, 2016.

137. Alireza Heidari, “Combined Theoretical and Computational Study of the Belousov–Zhabotinsky Chaotic Reaction and Curtius Rearrangement for Synthesis of Mechlorethamine, Cisplatin, Streptozotocin, Cyclophosphamide, Melphalan, Busulphan and BCNU as Anti–Cancer Drugs”, Insights Med Phys. 1: 2, 2016.

138. Alireza Heidari, “A Translational Biomedical Approach to Structural Arrangement of Amino Acids’ Complexes: A Combined Theoretical and Computational Study”, Transl Biomed. 7: 2, 2016.

139. Alireza Heidari, “Ab Initio and Density Functional Theory (DFT) Studies of Dynamic NMR Shielding Tensors and Vibrational Frequencies of DNA/RNA and Cadmium Oxide (CdO) Nanoparticles Complexes in Human Cancer Cells”, J Nanomedine Biotherapeutic Discov 6: e144, 2016.

140. Alireza Heidari, “Molecular Dynamics and Monte–Carlo Simulations for Replacement Sugars in Insulin Resistance, Obesity, LDL Cholesterol, Triglycerides, Metabolic Syndrome, Type 2 Diabetes and Cardiovascular Disease: A Glycobiological Study”, J Glycobiol 5: e111, 2016.

141. Alireza Heidari, “Synthesis and Study of 5–[(Phenylsulfonyl)Amino]–1,3,4–Thiadiazole–2–Sulfonamide as Potential Anti–Pertussis Drug Using Chromatography and Spectroscopy Techniques”, Transl Med (Sunnyvale) 6: e138, 2016.

142. Alireza Heidari, “Nitrogen, Oxygen, Phosphorus and Sulphur Heterocyclic Anti–Cancer Nano Drugs Separation in the Supercritical Fluid of Ozone (O3) Using Soave–Redlich–Kwong (SRK) and Pang–Robinson (PR) Equations”, Electronic J Biol 12: 4, 2016.

143. Alireza Heidari, “An Analytical and Computational Infrared Spectroscopic Review of Vibrational Modes in Nucleic Acids”, Austin J Anal Pharm Chem. 3(1): 1058, 2016.

144. Alireza Heidari, Christopher Brown, “Phase, Composition and Morphology Study and Analysis of Os–Pd/HfC Nanocomposites”, Nano Res Appl. 2: 1, 2016.

145. Alireza Heidari, Christopher Brown, “Vibrational Spectroscopic Study of Intensities and Shifts of Symmetric Vibration Modes of Ozone Diluted by Cumene”, International Journal of Advanced Chemistry, 4 (1) 5–9, 2016.

146.Alireza Heidari, “Study of the Role of Anti–Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues”, Arch Can Res. 4: 2, 2016.

147. Alireza Heidari, “Genomics and Proteomics Studies of Zolpidem, Necopidem, Alpidem, Saripidem, Miroprofen, Zolimidine, Olprinone and Abafungin as Anti–Tumor, Peptide Antibiotics, Antiviral and Central Nervous System (CNS) Drugs”, J Data Mining Genomics & Proteomics 7: e125, 2016.

148.Alireza Heidari, “Pharmacogenomics and Pharmacoproteomics Studies of Phosphodiesterase–5 (PDE5) Inhibitors and Paclitaxel Albumin–Stabilized Nanoparticles as Sandwiched Anti–Cancer Nano Drugs between Two DNA/RNA Molecules of Human Cancer Cells”, J Pharmacogenomics Pharmacoproteomics 7: e153, 2016.

149. Alireza Heidari, “Biotranslational Medical and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles–DNA/RNA Straight and Cycle Chain Complexes as Potent Anti–Viral, Anti–Tumor and Anti–Microbial Drugs: A Clinical Approach”, Transl Biomed. 7: 2, 2016.

150. Alireza Heidari, “A Comparative Study on Simultaneous Determination and Separation of Adsorbed Cadmium Oxide (CdO) Nanoparticles on DNA/RNA of Human Cancer Cells Using Biospectroscopic Techniques and Dielectrophoresis (DEP) Method”, Arch Can Res. 4: 2, 2016.

151. Alireza Heidari, “Cheminformatics and System Chemistry of Cisplatin, Carboplatin, Nedaplatin, Oxaliplatin, Heptaplatin and Lobaplatin as Anti–Cancer Nano Drugs: A Combined Computational and Experimental Study”, J Inform Data Min 1: 3, 2016.

152. Alireza Heidari, “Linear and Non–Linear Quantitative Structure–Anti–Cancer–Activity Relationship (QSACAR) Study of Hydrous Ruthenium (IV) Oxide (RuO2) Nanoparticles as Non–Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and Anti–Cancer Nano Drugs”, J Integr Oncol 5: e110, 2016.

153. Alireza Heidari, “Synthesis, Characterization and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles–Nucleic Acids Complexes Absence of Soluble Polymer as a Protective Agent Using Nucleic Acids Condensation and Solution Reduction Method”, J Nanosci Curr Res 1: e101, 2016.

154. Alireza Heidari, “Coplanarity and Collinearity of 4’–Dinonyl–2,2’–Bithiazole in One Domain of Bleomycin and Pingyangmycin to be Responsible for Binding of Cadmium Oxide (CdO) Nanoparticles to DNA/RNA Bidentate Ligands as Anti–Tumor Nano Drug”, Int J Drug Dev & Res 8: 007–008, 2016.

155. Alireza Heidari, “A Pharmacovigilance Study on Linear and Non–Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for the Prediction of Retention Time of Anti–Cancer Nano Drugs under Synchrotron Radiations”, J Pharmacovigil 4: e161, 2016.

156. Alireza Heidari, “Nanotechnology in Preparation of Semipermeable Polymers”, J Adv Chem Eng 6: 157, 2016.

157. Alireza Heidari, “A Gastrointestinal Study on Linear and Non–Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for Analysis 5–Aminosalicylates Nano Particles as Digestive System Nano Drugs under Synchrotron Radiations”, J Gastrointest Dig Syst 6: e119, 2016.

158. Alireza Heidari, “DNA/RNA Fragmentation and Cytolysis in Human Cancer Cells Treated with Diphthamide Nano Particles Derivatives”, Biomedical Data Mining 5: e102, 2016.

159. Alireza Heidari, “A Successful Strategy for the Prediction of Solubility in the Construction of Quantitative Structure–Activity Relationship (QSAR) and Quantitative Structure–Property Relationship (QSPR) under Synchrotron Radiations Using Genetic Function Approximation (GFA) Algorithm”, J Mol Biol Biotechnol 1: 1, 2016.

160. Alireza Heidari, “Computational Study on Molecular Structures of C20, C60, C240, C540, C960, C2160 and C3840 Fullerene Nano Molecules under Synchrotron Radiations Using Fuzzy Logic”, J Material Sci Eng 5: 282, 2016.

161. Alireza Heidari, “Graph Theoretical Analysis of Zigzag Polyhexamethylene Biguanide, Polyhexamethylene Adipamide, Polyhexamethylene Biguanide Gauze and Polyhexamethylene Biguanide Hydrochloride (PHMB) Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a–BNNTs) and Hexagonal Boron Nitride Nanotubes (h–BNNTs)”, J Appl Computat Math 5: e143, 2016.

162. Alireza Heidari, “The Impact of High Resolution Imaging on Diagnosis”, Int J Clin Med Imaging 3: 1000e101, 2016.

163. Alireza Heidari, “A Comparative Study of Conformational Behavior of Isotretinoin (13–Cis Retinoic Acid) and Tretinoin (All–Trans Retinoic Acid (ATRA)) Nano Particles as Anti–Cancer Nano Drugs under Synchrotron Radiations Using Hartree–Fock (HF) and Density Functional Theory (DFT) Methods”, Insights in Biomed 1: 2, 2016.

164. Alireza Heidari, “Advances in Logic, Operations and Computational Mathematics”, J Appl Computat Math 5: 5, 2016.

165. Alireza Heidari, “Mathematical Equations in Predicting Physical Behavior”, J Appl Computat Math 5: 5, 2016.

166. Alireza Heidari, “Chemotherapy a Last Resort for Cancer Treatment”, Chemo Open Access 5: 4, 2016.

167. Alireza Heidari, “Separation and Pre–Concentration of Metal Cations–DNA/RNA Chelates Using Molecular Beam Mass Spectrometry with Tunable Vacuum Ultraviolet (VUV) Synchrotron Radiation and Various Analytical Methods”, Mass Spectrom Purif Tech 2: e101, 2016.

168. Alireza Heidari, “Yoctosecond Quantitative Structure–Activity Relationship (QSAR) and Quantitative Structure–Property Relationship (QSPR) under Synchrotron Radiations Studies for Prediction of Solubility of Anti–Cancer Nano Drugs in Aqueous Solutions Using Genetic Function Approximation (GFA) Algorithm”, Insight Pharm Res. 1: 1, 2016.

169. Alireza Heidari, “Cancer Risk Prediction and Assessment in Human Cells under Synchrotron Radiations Using Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Properties Relationship (QSPR) Studies”, Int J Clin Med Imaging 3: 516, 2016.

170. Alireza Heidari, “A Novel Approach to Biology”, Electronic J Biol 12: 4, 2016.

171. Alireza Heidari, “Innovative Biomedical Equipment’s for Diagnosis and Treatment”, J Bioengineer & Biomedical Sci 6: 2, 2016.

172. Alireza Heidari, “Integrating Precision Cancer Medicine into Healthcare, Medicare Reimbursement Changes and the Practice of Oncology: Trends in Oncology Medicine and Practices”, J Oncol Med & Pract 1: 2, 2016.

173. Alireza Heidari, “Promoting Convergence in Biomedical and Biomaterials Sciences and Silk Proteins for Biomedical and Biomaterials Applications: An Introduction to Materials in Medicine and Bioengineering Perspectives”, J Bioengineer & Biomedical Sci 6: 3, 2016.

174. Alireza Heidari, “X–Ray Fluorescence and X–Ray Diffraction Analysis on Discrete Element Modeling of Nano Powder Metallurgy Processes in Optimal Container Design”, J Powder Metall Min 6: 1, 2017.

175. Alireza Heidari, “Biomolecular Spectroscopy and Dynamics of Nano–Sized Molecules and Clusters as Cross–Linking–Induced Anti–Cancer and Immune–Oncology Nano Drugs Delivery in DNA/RNA of Human Cancer Cells’ Membranes under Synchrotron Radiations: A Payload–Based Perspective”, Arch Chem Res. 1: 2, 2017.

176. Alireza Heidari, “Deficiencies in Repair of Double–Standard DNA/RNA–Binding Molecules Identified in Many Types of Solid and Liquid Tumors Oncology in Human Body for Advancing Cancer Immunotherapy Using Computer Simulations and Data Analysis”, J Appl Bioinforma Comput Biol, 6: 1, 2017.

177. Alireza Heidari, “Electronic Coupling among the Five Nanomolecules Shuts Down Quantum Tunneling in the Presence and Absence of an Applied Magnetic Field for Indication of the Dimer or other Provide Different Influences on the Magnetic Behavior of Single Molecular Magnets (SMMs) as Qubits for Quantum Computing”, Glob J Res Rev. 4: 2, 2017.

178. Alireza Heidari, “Polymorphism in Nano–Sized Graphene Ligand–Induced Transformation of Au38–xAgx/xCux(SPh–tBu)24 to Au36–xAgx/xCux(SPh–tBu)24 (x = 1–12) Nanomolecules for Synthesis of Au144–xAgx/xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p–MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] Nano Clusters as Anti–Cancer Nano Drugs”, J Nanomater Mol Nanotechnol, 6: 3, 2017.

179. Alireza Heidari, “Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research”, Int J Biomed Data Min 6: e103, 2017.

180. Alireza Heidari, “Study of Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Olympiadane Nanomolecules as Agent for Cancer Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy under Synchrotorn Radiation”, J Dev Drugs 6: e154, 2017.

181. Alireza Heidari, “A Novel Approach to Future Horizon of Top Seven Biomedical Research Topics to Watch in 2017: Alzheimer’s, Ebola, Hypersomnia, Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Microbiome/Antibiotic Resistance and Endovascular Stroke”, J Bioengineer & Biomedical Sci 7: e127, 2017.

182. Alireza Heidari, “Opinion on Computational Fluid Dynamics (CFD) Technique”, Fluid Mech Open Acc 4: 157, 2017.

183. Alireza Heidari, “Concurrent Diagnosis of Oncology Influence Outcomes in Emergency General Surgery for Colorectal Cancer and Multiple Sclerosis (MS) Treatment Using Magnetic Resonance Imaging (MRI) and Au329(SR)84, Au329–xAgx(SR)84, Au144(SR)60, Au68(SR)36, Au30(SR)18, Au102(SPh)44, Au38(SPh)24, Au38(SC2H4Ph)24, Au21S(SAdm)15, Au36(pMBA)24 and Au25(pMBA)18 Nano Clusters”, J Surgery Emerg Med 1: 21, 2017.

184. Alireza Heidari, “Developmental Cell Biology in Adult Stem Cells Death and Autophagy to Trigger a Preventive Allergic Reaction to Common Airborne Allergens under Synchrotron Radiation Using Nanotechnology for Therapeutic Goals in Particular Allergy Shots (Immunotherapy)”, Cell Biol (Henderson, NV) 6: 1, 2017.

185. Alireza Heidari, “Changing Metal Powder Characteristics for Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins Adjustment in Cancer Metastases Induced by Osteosarcoma, Chondrosarcoma, Carcinoid, Carcinoma, Ewing’s Sarcoma, Fibrosarcoma and Secondary Hematopoietic Solid or Soft Tissue Tumors”, J Powder Metall Min 6: 170, 2017.

186. Alireza Heidari, “Nanomedicine–Based Combination Anti–Cancer Therapy between Nucleic Acids and Anti–Cancer Nano Drugs in Covalent Nano Drugs Delivery Systems for Selective Imaging and Treatment of Human Brain Tumors Using Hyaluronic Acid, Alguronic Acid and Sodium Hyaluronate as Anti–Cancer Nano Drugs and Nucleic Acids Delivery under Synchrotron Radiation”, Am J Drug Deliv 5: 2, 2017.

187. Alireza Heidari, “Clinical Trials of Dendritic Cell Therapies for Cancer Exposing Vulnerabilities in Human Cancer Cells’ Metabolism and Metabolomics: New Discoveries, Unique Features Inform New Therapeutic Opportunities, Biotech’s Bumpy Road to the Market and Elucidating the Biochemical Programs that Support Cancer Initiation and Progression”, J Biol Med Science 1: e103, 2017.

188. Alireza Heidari, “The Design Graphene–Based Nanosheets as a New Nanomaterial in Anti–Cancer Therapy and Delivery of Chemotherapeutics and Biological Nano Drugs for Liposomal Anti–Cancer Nano Drugs and Gene Delivery”, Br Biomed Bull 5: 305, 2017.

189. Alireza Heidari, “Integrative Approach to Biological Networks for Emerging Roles of Proteomics, Genomics and Transcriptomics in the Discovery and Validation of Human Colorectal Cancer Biomarkers from DNA/RNA Sequencing Data under Synchrotron Radiation”, Transcriptomics 5: e117, 2017.

190. Alireza Heidari, “Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation”, Lett Health Biol Sci 2 (2): 1–4, 2017.

191. Alireza Heidari, “Treatment of Breast Cancer Brain Metastases through a Targeted Nanomolecule Drug Delivery System Based on Dopamine Functionalized Multi–Wall Carbon Nanotubes (MWCNTs) Coated with Nano Graphene Oxide (GO) and Protonated Polyaniline (PANI) in Situ During the Polymerization of Aniline Autogenic Nanoparticles for the Delivery of Anti–Cancer Nano Drugs under Synchrotron Radiation”, Br J Res, 4(3): 16, 2017.

192. Alireza Heidari, “Sedative, Analgesic and Ultrasound–Mediated Gastrointestinal Nano Drugs Delivery for Gastrointestinal Endoscopic Procedure, Nano Drug–Induced Gastrointestinal Disorders and Nano Drug Treatment of Gastric Acidity”, Res Rep Gastroenterol, 1:1, 2017.

193. Alireza Heidari, “Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Orphan Nano Drugs to Treat High Cholesterol and Related Conditions and to Prevent Cardiovascular Disease under Synchrotron Radiation”, J Pharm Sci Emerg Drugs 5: 1, 2017.

194. Alireza Heidari, “Non–Linear Compact Proton Synchrotrons to Improve Human Cancer Cells and Tissues Treatments and Diagnostics through Particle Therapy Accelerators with Monochromatic Microbeams”, J Cell Biol Mol Sci 2(1): 1–5, 2017.

195. Alireza Heidari, “Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood–Brain Barrier (BBB) Translocation to Targeted Deliver Anti–Cancer Nano Drugs into the Human Brain to Treat Alzheimer’s Disease under Synchrotron Radiation”, J Nanotechnol Material Sci 4(2): 1–5, 2017.

196. Ricardo Gobato, Alireza Heidari, “Calculations Using Quantum Chemistry for Inorganic Molecule Simulation BeLi2SeSi”, American Journal of Quantum Chemistry and Molecular Spectroscopy, Vol. 2, No. 3, Pages 37–46, 2017.

197. Alireza Heidari, “Different High–Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Lung Cancer Translational Anti–Cancer Nano Drugs Delivery Treatment Process under Synchrotron and X–Ray Radiations”, J Med Oncol. Vol. 1 No. 1: 1, 2017.

198. Alireza Heidari, “A Modern Ethnomedicinal Technique for Transformation, Prevention and Treatment of Human Malignant Gliomas Tumors into Human Benign Gliomas Tumors under Synchrotron Radiation”, Am J Ethnomed, Vol. 4 No. 1: 10, 2017.

199. Alireza Heidari, “An Investigation of the Role of DNA as Molecular Computers: A Computational Study on the Hamiltonian Path Problem”, International Journal of Scientific & Engineering Research, Vol. 5, Issue 1, Pages 1884–1889, 2014.

200. Alireza Heidari, “Active Targeted Nanoparticles for Anti–Cancer Nano Drugs Delivery across the Blood–Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer’s Diseases Using Chemical Modifications of Anti–Cancer Nano Drugs or Drug–Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation”, J Med Chem Toxicol, 2(3): 1–5, 2017.

201. Alireza Heidari, “Investigation of Medical, Medicinal, Clinical and Pharmaceutical Applications of Estradiol, Mestranol (Norlutin), Norethindrone (NET), Norethisterone Acetate (NETA), Norethisterone Enanthate (NETE) and Testosterone Nanoparticles as Biological Imaging, Cell Labeling, Anti–Microbial Agents and Anti–Cancer Nano Drugs in Nanomedicines Based Drug Delivery Systems for Anti–Cancer Targeting and Treatment”, Parana Journal of Science and Education (PJSE)–V.3, n.4, (10–19) October 12, 2017.

202. Alireza Heidari, “A Comparative Computational and Experimental Study on Different Vibrational Biospectroscopy Methods, Techniques and Applications for Human Cancer Cells in Tumor Tissues Simulation, Modeling, Research, Diagnosis and Treatment”, Open J Anal Bioanal Chem 1(1): 014–020, 2017.

203. Alireza Heidari, “Combination of DNA/RNA Ligands and Linear/Non–Linear Visible–Synchrotron Radiation–Driven N–Doped Ordered Mesoporous Cadmium Oxide (CdO) Nanoparticles Photocatalysts Channels Resulted in an Interesting Synergistic Effect Enhancing Catalytic Anti–Cancer Activity”, Enz Eng 6: 1, 2017.

204. Alireza Heidari, “Modern Approaches in Designing Ferritin, Ferritin Light Chain, Transferrin, Beta–2 Transferrin and Bacterioferritin–Based Anti–Cancer Nano Drugs Encapsulating Nanosphere as DNA–Binding Proteins from Starved Cells (DPS)”, Mod Appro Drug Des. 1(1). MADD.000504. 2017.

205. Alireza Heidari, “Potency of Human Interferon β–1a and Human Interferon β–1b in Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus Enter and Targets Liver Cells”, J Proteomics Enzymol 6: 1, 2017.

206. Alireza Heidari, “Transport Therapeutic Active Targeting of Human Brain Tumors Enable Anti–Cancer Nanodrugs Delivery across the Blood–Brain Barrier (BBB) to Treat Brain Diseases Using Nanoparticles and Nanocarriers under Synchrotron Radiation”, J Pharm Pharmaceutics 4(2): 1–5, 2017.

207. Alireza Heidari, Christopher Brown, “Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti–Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems”, Ann Adv Chem. 1(2): 061–069, 2017.

208. Alireza Heidari, “Vibrational Spectroscopy of Nucleic Acids”, Wahid Ali Khan (Editor), “Basic Biochemistry”, Austin Publishing Group (APG)/Austin Publications LLC, ISBN: 978–0–9971499–2–0, Pages 1–18, Jersey City, New Jersey, USA, 2016.

209. Alireza Heidari, “High–Resolution Simulations of Human Brain Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron Radiation”, J Transl Res 1(1): 1–3, 2017.

210. Alireza Heidari, “Investigation of Anti–Cancer Nano Drugs’ Effects’ Trend on Human Pancreas Cancer Cells and Tissues Prevention, Diagnosis and Treatment Process under Synchrotron and X–Ray Radiations with the Passage of Time Using Mathematica”, Current Trends Anal Bioanal Chem, 1 (1): 36–41, 2017.

211. Alireza Heidari, “Pros and Cons Controversy on Molecular Imaging and Dynamics of Double–Standard DNA/RNA of Human Preserving Stem Cells–Binding Nano Molecules with Androgens/Anabolic Steroids (AAS) or Testosterone Derivatives through Tracking of Helium–4 Nucleus (Alpha Particle) Using Synchrotron Radiation”, Arch Biotechnol Biomed. 1 (1): 067–0100, 2017.

212. Alireza Heidari, “Visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR Spectroscopy and Self–Organizing Maps under Synchrotron Radiation”, SOJ Mater Sci Eng 5 (2): 1–6, 2017.

213. Alireza Heidari, “Cavity Ring–Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Enliven: Challenges Cancer Detect Ther 4 (2): e001, 2017.

214. Alireza Heidari, “Laser Spectroscopy, Laser–Induced Breakdown Spectroscopy and Laser–Induced Plasma Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Int J Hepatol Gastroenterol, 3 (4): 079–084, 2017.

215. Alireza Heidari, “Time–Resolved Spectroscopy and Time–Stretch Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Enliven: Pharmacovigilance and Drug Safety 4 (2): e001, 2017.

216. Alireza Heidari, “Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiation”, Open J Anal Bioanal Chem 1 (1): 021–026, 2017.

217. Alireza Heidari, “Electron Phenomenological Spectroscopy, Electron Paramagnetic Resonance (EPR) Spectroscopy and Electron Spin Resonance (ESR) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Austin J Anal Pharm Chem. 4 (3): 1091, 2017.

218. Alireza Heidari, “Therapeutic Nanomedicine Different High–Resolution Experimental Images and Computational Simulations for Human Brain Cancer Cells and Tissues Using Nanocarriers Deliver DNA/RNA to Brain Tumors under Synchrotron Radiation with the Passage of Time Using Mathematica and MATLAB”, Madridge J Nano Tech. Sci. 2 (2): 77–83, 2017.

219. Alireza Heidari, “A Consensus and Prospective Study on Restoring Cadmium Oxide (CdO) Nanoparticles Sensitivity in Recurrent Ovarian Cancer by Extending the Cadmium Oxide (CdO) Nanoparticles–Free Interval Using Synchrotron Radiation Therapy as Antibody–Drug Conjugate for the Treatment of Limited–Stage Small Cell Diverse Epithelial Cancers”, Cancer Clin Res Rep, 1: 2, e001, 2017.

220. Alireza Heidari, “A Novel and Modern Experimental Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White Synchrotron Radiation”, Cancer Sci Res Open Access 4 (2): 1–8, 2017.

221. Alireza Heidari, “Different High–Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Breast Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron and X–Ray Radiations”, J Oral Cancer Res 1 (1): 12–17, 2017.

222. Alireza Heidari, “Vibrational Decihertz (dHz), Centihertz (cHz), Millihertz (mHz), Microhertz (μHz), Nanohertz (nHz), Picohertz (pHz), Femtohertz (fHz), Attohertz (aHz), Zeptohertz (zHz) and Yoctohertz (yHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, International Journal of Biomedicine, 7 (4), 335–340, 2017.

223. Alireza Heidari, “Force Spectroscopy and Fluorescence Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, EC Cancer, 2 (5), 239–246, 2017.

224. Alireza Heidari, “Photoacoustic Spectroscopy, Photoemission Spectroscopy and Photothermal Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, BAOJ Cancer Res Ther, 3: 3, 045–052, 2017.

225. Alireza Heidari, “J–Spectroscopy, Exchange Spectroscopy (EXSY), Nucle¬ar Overhauser Effect Spectroscopy (NOESY) and Total Correlation Spectroscopy (TOCSY) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, EMS Eng Sci J, 1 (2): 006–013, 2017.

226. Alireza Heidari, “Neutron Spin Echo Spectroscopy and Spin Noise Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Int J Biopharm Sci, 1: 103–107, 2017.

227. Alireza Heidari, “Vibrational Decahertz (daHz), Hectohertz (hHz), Kilohertz (kHz), Megahertz (MHz), Gigahertz (GHz), Terahertz (THz), Petahertz (PHz), Exahertz (EHz), Zettahertz (ZHz) and Yottahertz (YHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, Madridge J Anal Sci Instrum, 2 (1): 41–46, 2017.

228. Alireza Heidari, “Two–Dimensional Infrared Correlation Spectroscopy, Linear Two–Dimensional Infrared Spectroscopy and Non–Linear Two–Dimensional Infrared Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time”, J Mater Sci Nanotechnol 6 (1): 101.

229. Alireza Heidari, “Fourier Transform Infrared (FTIR) Spectroscopy, Near–Infrared Spectroscopy (NIRS) and Mid–Infrared Spectroscopy (MIRS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time”, Int J Nanotechnol Nanomed, Volume 3, Issue 1, Pages 1–6, 2018.

230. Alireza Heidari, “Infrared Photo Dissociation Spectroscopy and Infrared Correlation Table Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time”, Austin Pharmacol Pharm, 3 (1): 1011, 2018.

231. Alireza Heidari, “Novel and Transcendental Prevention, Diagnosis and Treatment Strategies for Investigation of Interaction among Human Blood Cancer Cells, Tissues, Tumors and Metastases with Synchrotron Radiation under Anti–Cancer Nano Drugs Delivery Efficacy Using MATLAB Modeling and Simulation”, Madridge J Nov Drug Res, 1 (1): 18–24, 2017.

232. Alireza Heidari, “Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Open Access J Trans Med Res, 2 (1): 00026–00032, 2018.

233. Marcia Regina Risso Gobato, Ricardo Gobato, Alireza Heidari, “Planting of Jaboticaba Trees for Landscape Repair of Degraded Area”, Landscape Architecture and Regional Planning, Vol. 3, No. 1, 2018, Pages 1–9, 2018.

234. Alireza Heidari, “Fluorescence Spectroscopy, Phosphorescence Spectroscopy and Luminescence Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time”, SM J Clin. Med. Imaging, 4 (1): 1018, 2018.

235. Alireza Heidari, “Nuclear Inelastic Scattering Spectroscopy (NISS) and Nuclear Inelastic Absorption Spectroscopy (NIAS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, Int J Pharm Sci, 2 (1): 1–14, 2018.

236. Alireza Heidari, “X–Ray Diffraction (XRD), Powder X–Ray Diffraction (PXRD) and Energy–Dispersive X–Ray Diffraction (EDXRD) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, J Oncol Res; 2 (1): 1–14, 2018.

237. A. Heidari, “Correlation Two–Dimensional Nuclear Magnetic Resonance (NMR) (2D– NMR) (COSY) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, EMS Can Sci, 1–1–001, 2018.

238. Alireza Heidari, “Thermal Spectroscopy, Photothermal Spectroscopy, Thermal Microspectroscopy, Photothermal Microspectroscopy, Thermal Macrospectroscopy and Photothermal Macrospectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, SM J Biometrics Biostat, 3 (1): 1024, 2018.

239. Alireza Heidari, “A Modern and Comprehensive Experimental Biospectroscopic Comparative Study on Human Common Cancers’ Cells, Tissues and Tumors before and after Synchrotron Radiation Therapy”, Open Acc J Oncol Med. 1 (1), 2018.

240. Alireza Heidari, “Heteronuclear Correlation Experiments such as Heteronuclear Single– Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple–Quantum Correlation Spectroscopy (HMQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Endocrinology and Thyroid Cancer Cells and Tissues under Synchrotron Radiation”, J Endocrinol Thyroid Res, 3 (1): 555603, 2018.

241. Alireza Heidari, “Nuclear Resonance Vibrational Spectroscopy (NRVS), Nuclear Inelastic Scattering Spectroscopy (NISS), Nuclear Inelastic Absorption Spectroscopy (NIAS) and Nuclear Resonant Inelastic X–Ray Scattering Spectroscopy (NRIXSS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, Int J Bioorg Chem Mol Biol. 6 (1e): 1–5, 2018.

242. Alireza Heidari, “A Novel and Modern Experimental Approach to Vibrational Circular Dichroism Spectroscopy and Video Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White and Monochromatic Synchrotron Radiation”, Glob J Endocrinol Metab. 1 (3). GJEM. 000514–000519, 2018.

243. Alireza Heidari, “Pros and Cons Controversy on Heteronuclear Correlation Experiments such as Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple–Quantum Correlation Spectroscopy (HMQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, EMS Pharma J. 1 (1): 002–008, 2018.

244. Alireza Heidari, “A Modern Comparative and Comprehensive Experimental Biospectroscopic Study on Different Types of Infrared Spectroscopy of Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, J Analyt Molecul Tech. 3 (1): 8, 2018.

245. Alireza Heidari, “Investigation of Cancer Types Using Synchrotron Technology for Proton Beam Therapy: An Experimental Biospectroscopic Comparative Study”, European Modern Studies Journal, Vol. 2, No. 1, 13–29, 2018.

246. Alireza Heidari, “Saturated Spectroscopy and Unsaturated Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation”, Imaging J Clin Medical Sci. 5 (1): 001–007, 2018.

247. Alireza Heidari, “Small–Angle Neutron Scattering (SANS) and Wide–Angle X–Ray Diffraction (WAXD) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, Int J Bioorg Chem Mol Biol. 6 (2e): 1–6, 2018.

248. Alireza Heidari, “Investigation of Bladder Cancer, Breast Cancer, Colorectal Cancer, Endometrial Cancer, Kidney Cancer, Leukemia, Liver, Lung Cancer, Melanoma, Non– Hodgkin Lymphoma, Pancreatic Cancer, Prostate Cancer, Thyroid Cancer and Non– Melanoma Skin Cancer Using Synchrotron Technology for Proton Beam Therapy: An Experimental Biospectroscopic Comparative Study”, Ther Res Skin Dis 1 (1), 2018.

249. Alireza Heidari, “Attenuated Total Reflectance Fourier Transform Infrared (ATR– FTIR) Spectroscopy, Micro–Attenuated Total Reflectance Fourier Transform Infrared (Micro–ATR–FTIR) Spectroscopy and Macro–Attenuated Total Reflectance Fourier Transform Infrared (Macro–ATR–FTIR) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time”, International Journal of Chemistry Papers, 2 (1): 1–12, 2018.

250. Alireza Heidari, “Mössbauer Spectroscopy, Mössbauer Emission Spectroscopy and 57 Fe Mössbauer Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation”, Acta Scientific Cancer Biology 2.3: 17–20, 2018.

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