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Chemical Constituents of the Leaves of Eberhardtia Aurata (Sapotaceae)

Chemical Constituents of the Leaves of Eberhardtia Aurata (Sapotaceae)
V. T. Nguyen, V. C. Pham, T. M. H. Doan, B. N. Truong, T. H. Tran,  M. Litaudon and V. M. Chau
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ABSTRACT
In the framework of scientific co-operation between the Institute of Marine Biochemistry, (Vietnam Academy of Science and Technology) and the Institute of Natural Product Chemistry (Natural Product Chemistry, France) on phytochemistry of the Vietnamese flora, the plant Eberhardtia aurata (Pierre ex Dubard) Lecomte was selected for its cytotoxic activity on KB cell lines [14.6% inhibition at 1 μg/ml for the ethyl acetate (EtOAc) extract of the leaves]. From the EtOAc extract of the leaves of this plant, 4 oleanane triterpenes, taraxerol (1), taraxerone (2), taraxeryl acetate (3), 3 β-octacosanoyloxy-12-oleanen-28-ol (4) and 1 sterol, spinasterol (5) were isolated. Their structures were elucidated by using MS and NMR spectroscopic methods, including 2D NMR spectroscopy (COSY, HMQC, HMBC).

Key words: Eberhardtia aurata; Sapotaceae; triterpenes; ethyl acetate; cytotoxic activity

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